Hydrocodone 10-500 mg – Medical Uses, Prescription Requirements, Benefits & Safety Information | BeOnMed

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Hydrocodone is an opioid medication historically used in combination with acetaminophen to manage moderate to severe pain. The Hydrocodone 10-500 mg formulation contained 10 mg of hydrocodone and 500 mg of acetaminophen per tablet. Although this combination was previously available as a prescription medication, it is important to understand that the 10/500 mg strength is a legacy formulation. The FDA requested that manufacturers limit acetaminophen in prescription combination products to 325 mg per dosage unit because of concerns about serious liver damage.

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